Genetic resistance is readily overcome by pathogens and engineered disease resistance provides a viable, flexible, and durable alternative to genetic resistance. To engineer immunity and establish resistance to plant viruses, we develop CRISPR-based technologies that specifically target pathogens. We also engineer and use plant viruses as synthetic biology devices for the bioproduction of select chemicals and compounds, including pharmaceuticals and biologics. We harness the power of viruses in synthetic biology applications to turn plants into a sustainable green bio-factories for diverse high-value products.